The Synthesis and X-ray Studies of 6-pyrrolidinyl-2-triazolyl Purine Arabinonucleoside

Authors

  • Irina Novosjolova Riga Technical University
  • Ērika Bizdēna Riga Technical University
  • Sergey Belyakov Latvian Institute of Organic Synthesis
  • Māris Turks Riga Technical University

DOI:

https://doi.org/10.7250/msac.2013.007

Abstract

C(6)-Pyrrolidinyl derivative with triazolyl moiety at C(2)-position was obtained from 2,6-bis-triazolylpurine arabinonucleoside via C(6)-regioselective nucleophilic substituon of 1,2,3-triazolyl moiety with pyrrolidine. The obtained compound was studied by NMR, X-ray, UV/VIS and emission spectra. Pyranose form of arabinose residue and α-configuration of the obtained compound were unambiguously proven by NMR and X-ray studies.

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